The Tigers hit three homers off Indians starter Josh Tomlin to beat the Tribe 4-1. The Tigers now hold a two-and-a-half game lead over the Indians.
Austin Jackson hit a two-run shot off Tomlin in the sixth to give the Tigers a 2-0 lead.
Carlos Santana scored on a wild pitch in the seventh to cut the lead to 2-1.
But Tomlin gave up back-to-back jacks in the bottom half of the inning to Alex Avila and former Indian Jhonny Peralta to give the Tigers a 4-1 victory.
Tomlin gave up four runs in six and two thirds innings.
Tigers Max Scherzer went seven innings giving up one run on five hits.