Roy Hibbert lead six Indiana players in double-digits with 18 points as the Pacers won in Cleveland 99-89.
The Cavs lead 45-44 at the break, but the Pacers scored 33 points in the third quarter to break the game open and they never looked back.
Kyrie Irving lead the Cavaliers with 17 points, Dion Waiters scored 11. Tyler Zeller started for Anderson Varejao (knee) at center and responded with 12 points, seven rebounds and two blocked shots.
The Cavaliers play in Milwaukee on Saturday night.