Trey Lewis scored a game-high 18 points, but Cleveland State fell at sixth-ranked Virginia, 70-54, on Thursday night in John Paul Jones Arena.
CSU fell to 5-6 this season, while the Cavaliers improved to 10-0.
Lewis hit four three-pointers and added a pair of rebounds, while Anton Grady and Charlie Lee both scored eight points. Kaza Keane scored six points off the bench.
Justin Anderson and Malcolm Brogdan scored 16 points each to lead Virginia.
"I thought we played hard tonight," head coach Gary Waters said. "They are a very good team, worthy of their ranking and have a very strong defense. We had good opportunities, but just missed shots. It was good to play a team like this that gets down and guards you."
The Cavaliers took a 31-18 lead at the half as both teams struggled from the field. The teams combined to shoot just 15-of-46 from the floor, but Virginia used a 15-of-19 effort at the free throw line to build the 13-point halftime lead.
The Vikings did not go to the line in the opening 20 minutes.
"I told them at halftime that was the difference in the game," Waters said. "I thought we did a better job of attacking the basket in the second half."
UVA opened up a 20 point lead (49-29) with 14 minutes to play, but seven straight points by the Vikings brought CSU within 49-36, forcing a Cavalier timeout.
The Cavaliers went to Anderson out of the timeout and he responded with a three-point play to stop the Viking run and UVA would lead the rest of the way.
CSU shot 19-of-52 (.365) from the floor and hit seven three's.
The Cavaliers, who came into the game as the top scoring defense team in the country (47.4 ppg), shot .500 (22-44) from the field and held a 32-26 advantage on the glass.
The Vikings are back in action on Sunday (Dec. 21) when CSU hosts San Francisco at 1:00 p.m. in the Wolstein Center. The game will be broadcast live on SportsTime Ohio and on AM 1420 WHK.