Velosano "Bike To Cure" begins Saturday morning, but the party had already started by Friday afternoon.
The challenging annual cycling event raises money for cancer research.
It's a disease that hits close to home for Mike Toth.
"A few years ago my wife was diagnosed with breast cancer and went through the full treatment, surgery, chemo and all," Toth said.
His inspiration will be right by his side for the ride this weekend. His wife Mary is a breast cancer survivor, recently diagnosed with lymphoma.
"I continue to feel fortunate through all of that," said Mary Toth. "We live in Cleveland. We have access to the best medical care there is and my cancer was caught early and it is a treatable disease."
That's what Velosano is all about. It means "swift cure" in Latin, Cleveland Clinic's goal with every penny raised.
Mary is proof the Clinic's research works. She's hoping it can do the same for her father.
"My dad is currently battling cancer as well and I will be turning to my dad and riding in his honor," Mary said.
More than 1,200 cyclists will take part in Velosano. Each rider makes a choice to pedal between 12 and 200 miles through northeast Ohio.
The Toths will ride a combined 150 miles. It's no easy task, but when you have this much support you can achieve anything.
"The physical pain we endure is nothing compared to the physical and emotional pain of the reason we are riding," Mike Toth added.
Last year, Velosano raised $1.9 million. This year it is at $2.3 million with two days of fundraising left.
Click here to learn more about this weekend's ride.