The new routes will start on April 14.
Frontier is also bringing back seasonal service to Atlanta, Denver, Raleigh/Durham and Seattle.
"We are very pleased that Frontier has decided to grow again at CLE," said Interim Director Fred Szabo. "Their expansion to 14 markets including seasonal service makes them the second largest airline at CLE in terms of nonstop markets."
Including seasonal flying, Frontier will offer service nonstop to Atlanta, Cancun, Denver, Ft. Myers, Las Vegas, Los Angeles, Orlando, Philadelphia, Phoenix, Portland, Raleigh/Durham, Seattle, San Francisco and Tampa.
Fares in the new markets will be as low as $59.