Miles is averaging 17 points a game in four games against Cleveland this season. He is also shooting 56 percent from three and 61.7 percent from the field against the Cavs.
"Every time he sees us he plays well. So we got to do a good job of being really locked into him, knowing where he's at, at all times and try to take him out of the series," Lue said.
Cleveland gave up 107 points a game this season. The Cavs coach said defense is a focus this series.
"Having the right coverages, everyone being on the same page," Lue said.
The Pacers leading scorer is Paul George. The Indiana forward is averaging 23.7 points a game. He is also shooting 46 percent from the field.
"We just got to take away his easy baskets, or easy layups or getting to the basket or not getting back in transition, take away those baskets," Lue said.