According to vegasinsider.com, Pittsburgh was originally listed as a 9.5-point favorite. The total for the game at 1 p.m. on Sept. 10 is set at 46.5 points.
Rookie DeShone Kizer will be the starting quarterback for the Browns on Sunday.
"This rivalry is one that shows you what northern, Midwest football is," Kizer said.
This will also be the first time Joe Haden plays defensive back for the Pittsburgh Steelers.
Haden spent seven years with Cleveland, he was cut by the team on Aug. 30.
The last time the Browns beat the Steelers was on Oct. 12, 2014. It was only the second time in his career Steelers quarterback Ben Roethlisberger lost to the Browns.
Good Morning Football host Kyle Brandt thinks the Browns will upset Pittsburgh. Brandt said the Browns have a lot of new players the Steelers aren't used to playing.
Tickets for the game are still available.
The game will be broadcast on Cleveland 19 at 1 p.m. on Sept. 10.