The injury happened in the bottom of the first inning.
Encarnacion was heading to third base during a Jay Bruce line drive, but had to return to second.
As Encarnacion was headed back to the bag, he rolled his ankle.
While leaving the field Encarnacion could not put any weight on his right foot.
Cleveland 19 sports photographer Dan Wagner saw Encarnacion leaving the tunnel with his ankle in a boot, he was using crutches for support.
Michael Brantley replaced Encarnacion during game two.
We will update this story as more information becomes available.