CLEVELAND, OH (WOIO) - It happened on East 99th Street around 1 a.m.
An 86-year-old female, a 60-year-old male, and a 30-year-old female were killed in the blaze.
Fire officials said the victims were members of the same family.
Their names are not being released at this time.
A Cleveland firefighter and an EMS worker were injured. Both were taken to the hospital, treated and released.
Investigators say there were no working smoke detectors inside the house.
No word yet on what caused the fire.